Valve disease in cardiac amyloidosis: an echocardiographic score

Abstract Background Cardiac amyloidosis (CA) may affect all cardiac structures, including the valves. Methods From 423 patients undergoing a diagnostic workup for CA we selected 2 samples of 20 with amyloid transthyretin (ATTR-) or light-chain (AL-) CA, and age- sex-matched controls. We chose 31 echocardiographic items related to mitral, aortic tricuspid valves, giving value 1 each abnormal item. Results Patients ATTR-CA displayed more often shortened/hidden restricted posterior mitral valve leaflet (PMVL), thickened chordae tendineae stenosis than those AL-CA, less frequent PMVL calcification matched Score values were 15.8 (13.6–17.4) in ATTR-CA, 11.0 (9.3–14.9) 12.8 (11.1–14.4) controls, (9.1–13.0) AL-CA controls (p=0.004 ATTR- vs. 0.009 their 0.461 controls). Area under curve diagnose 0.782 0.773 LV hypertrophy. Conclusions have prominent impairment structure function, higher score values. The is quite effective identifying among unexplained Funding Acknowledgement Type funding sources: None.